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Saturday, August 8, 2020 | History

2 edition of fetal endocrine pancreas found in the catalog.

fetal endocrine pancreas

F.A. van Assche

fetal endocrine pancreas

a quantitative morphological approach.

by F.A. van Assche

  • 292 Want to read
  • 13 Currently reading

Published in [Leuven] .
Written in English

    Subjects:
  • Fetus,
  • Pancreas

  • Classifications
    LC ClassificationsQM611 A77
    The Physical Object
    Pagination99p.
    Number of Pages99
    ID Numbers
    Open LibraryOL21850571M

    Fetal hyperinsulinemia is assumed to play a key role in the pathogenesis of diabetic fetopathy. To investigate the role of enhanced fetal B-cell mass as one cause of fetal hyperinsulinemia during diabetic pregnancy, we studied human fetal pancreatic slices from diabetic women (FDW) with poor metabolic control and nondiabetic women (FNDW) between 11 and 26 wk of pregnancy, morphometrically and.   The fetal pancreas expresses IGF-I, IGF-II and IGF binding protein 3 during late gestation As in other fetal tissues, IGF-II is the predominant IGF in the pancreas and is localised to the islets and duct epithelial ce Both IGF-I and IGF-II are mitogens in the fetal pancreas and lead to an increase in islet cell mass

      IntroductionCigarette smoking in pregnancy is a common cause of fetal growth restriction. We aimed to investigate endocrine pancreatic function of mother–infant dyads in relation to cigarette smoking, as a possible mechanism for the poor fetal sProspective study of smoking mothers (10 cigarettes or more per day, self-reported to the midwife) and non-smoker control mothers . Pancreas. The human fetal pancreas begins to develop by the fourth week of gestation. Five weeks later, the pancreatic alpha and beta cells have begun to emerge. Reaching eight to ten weeks into development, the pancreas starts producing insulin, glucagon, somatostatin, and pancreatic polypeptide. During the early stages of fetal development, the number of pancreatic alpha cells .

    a morphological study of the endocrine pancreas in human pregnancy F. A. Van Assche The Unit for the Study of Reproduction, Department of Obstetrics and Gynaecology, Academisch Ziekenhuis St Rufaëd (KUL), Capucienenv Leuven, Belgium. The text first covers the differentiation and growth of the endocrine pancreas, and then proceeds to tackling α- and ß-cells. The seventh part details pancreatic islets and diabetes. The book will be of great use to students, researchers, and practitioners of medicine. Control of Endocrine Function in Organ Cultures of Fetal Rat.


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Fetal endocrine pancreas by F.A. van Assche Download PDF EPUB FB2

The fetal hypothalamo-pituitary (H-P) neuroendocrine system develops early in gestation and is greatly affected by the placenta, which fetal endocrine pancreas book is a dynamic endocrine system unique to the state of pregnancy.

The developing H-P axis plays an important modulating role on other fetal organ systems, as well as preparing the fetus for extrauterine life. Endocrine disorders affecting the fetus or neonate Hypothalamus and pituitary Pineal Thyroid (agenesis, hypothyroidism, fetal Graves’, etc.) Disorders of Calcium, Phosphorus and Bone Metabolism During Fetal and Neonatal Development Pancreas and carbohydrate metabolism (diabetes and hypoglycemia) Book Description.

This book is intended to give readers a “quick look” at metabolic and endocrine physiology. Emphasis is placed on instructional figures, flow diagrams and tables, while text material has been held to a minimum.

In general, the endocrine system is first defined and described, and then each endocrine gland is discussed. Figure Pancreas The pancreatic exocrine function involves the acinar cells secreting digestive enzymes that are transported into the small intestine by the pancreatic duct.

Its endocrine function involves the secretion of insulin (produced by fetal endocrine pancreas book cells) and glucagon (produced by alpha cells) within the pancreatic islets. This chapter discusses endocrine pancreas of the pregnant mother, fetus, and newborn.

Throughout pregnancy, the maternal endocrine pancreas must adapt to fulfill the metabolic requirements of the developing conceptus. The constant drain of nutrients across the placenta represents an ever-increasing challenge to maternal homeostatic by: 8.

The development of the fetal and postnatal endocrine pancreas has been studied in depth in rodents (Jørgensen et al., ) and humans (Polak et al., ; Béringue et al., ) but not in other mammals. The objective of this work was to describe the differentiation and growth of alpha and beta cells from early fetal to postnatal life in the Beagle dog.

The organization of fetal, neonatal, and adult pancreas was analyzed by confocal microscopy after immunostaining with specific hormones as markers of the endocrine pancreas and trypsin as a marker of acinar cells (Fig. 4A, B and C). In adult pancreases, well-defined islets were surrounded by trypsin-positive acinar cells.

The ontogeny of the endocrine pancreas in the fetal/newborn baboon model provides insight into the normal pancreas development from late gestation through the neonatal period.

Furthermore, the presence of pancreatic cells with both, endocrine and exocrine phenotypes during late gestation, may have long term implications if born during this critical period of development. The pancreas is a two-headed organ, not only in origin but also in function.

In origin, the pancreas develops from two separate primordia. In function, the organ has both endocrine function in relation to regulating blood glucose (and also other hormone secretions) and gastrointestinal function as an exocrine (digestive) organ, see exocrine pancreas.

Samols E () The history of the endocrine pancreas. In: Samols E (ed) The endocrine pancreas. Raven, New York, pp 1–12 Google Scholar. Schaeffer LD, Wilder ML, Williams RH () Secretion and content of insulin and glucagon in human fetal pancreas slices in vitro. Bryson JM, Tuch BE, Baxter RC () Production of insulinlike growth factor-II by human fetal pancreas in culture.

J Endocrinol – PubMed CrossRef Google Scholar De Giorgio R, Sternini C, Brecha NC, Widdison AL, Karanjia ND, Reber HA, Go VLW () Pattern of innervation of vasoactive intestinal polypeptide, neuropeptide Y, and gastrin-releasing peptide immunoreactive.

the fetal Beagle dog beta cells emerge from the pancreatic bud at midgesta-tion, but the endocrine structure is mature only in early postnatal life. The ontogenesis of the endocrine pancreas demonstrated in dogs resembles that reported in rats and mice.

In contrast, human beta cells appear earlier, at the beginning of the second trimester of. The human endocrine pancreas is composed of four major cell types, A- B- D- and PP-cells, which are distinguished by routine staining procedures, immuno-cytochemistry and electron microscopy.

The fetal endocrine pancreas. Contrib Gynaecol Obstet Chapter 1. Islets of Langerhans and their devel~pment. * Adult pancreatic islet anatomy. In the experimental work of this thesis, hormone and protein expression patterns of human adult pancreatic islets were used for comparison with those in human fetal pancreata.

fetal pancreas by culturing tissue explants with or without M-CSF and analyzing the presence of macrophages thereafter. To investigate the role of pancreatic macrophages in endocrine tissue development, we have studied, in parallel, the develop-ment of insulin- and glucagon-producing cells in these cul-tured fetal pancreas explants.

The endocrine system resides within specific endocrine organs and both organs and tissues with other specific functions. Epithelia (ectoderm and endoderm) form the majority of the.

the fetal endocrine pancreas is a tightly coordinated process, both spatially and temporally, and is regulated both by positive and negative signals. This study examines, at the ultrastructural level, wheth-er the fetal porcine endocrine pancreas develops normally after transplantation under the.

The pancreas is a long, slender organ, most of which is located posterior to the bottom half of the stomach ().Although it is primarily an exocrine gland, secreting a variety of digestive enzymes, the pancreas has an endocrine function.

Its pancreatic islets—clusters of cells formerly known as the islets of Langerhans—secrete the hormones glucagon, insulin, somatostatin, and pancreatic. The fetal endocrine system commences development early in gestation and plays a modulating role on the various physiological organ systems and prepares the fetus for life after birth.

Our current article provides an overview of the current knowledge of several aspects of this vast field of fetal endocrinology and the role of endocrine system on. The pancreas is an accessory organ and exocrine gland of the digestive system, as well as a hormone producing endocrine is a retroperitoneal organ consisting of five parts and an internal system of ducts.

The pancreas is supplied by pancreatic arteries stemming from surrounding vessels and is innervated by the vagus nerve (CN X), celiac plexus, and superior mesenteric plexus. The pancreas is a large gland located in the upper left abdomen behind the stomach, as shown in the figure below.

The pancreas is about 15 centimeters (6 in.) long; and it has a flat, oblong shape. Structurally, the pancreas is divided into a head, body, and tail. Functionally, the pancreas serves as both an endocrine gland and an exocrine gland.CPHN Cells Do Not Replicate in Fetal and Infant Pancreas.

Endocrine cells expand by replication during late fetal and early neonatal life in humans ().Since CPHN cells may represent a precursor to fully differentiated endocrine cells, we quantified replication of CPHN cells in pancreatic tissue from fetuses and infants by use of Ki67, chromograninA and a cocktail of islet endocrine hormones.The unique features of the endocrine tissue of the fetal and neonatal pancreas must be considered before drawing conclusions as to their possible causative role in either presumed or clinically.